After 7 hours, I became pretty sedated and stoned with pronounced red eye and serious cotton mouth. My thinking was pretty scambled in a good, well at least fun way. At this point it became hard to carry on a conversation and I went to sleep around T+9 hours. Woke up today around T+18 hours with no school, work or general responsibility. I have pretty much watched T.V. all day with little motivation to do anything else.

On a more academic note, this article by Branden & Nichols: http://molpharm.aspetjournals.org/cgi/content/full/72/5/1200 investigates the binding of serine residues in the 5-HT2A receptor to various hallucinogens. They note that polar substituents on the aromatic ring of hallucinogens such as DOI interact with particular serine residues.

Safrole, elemicin and myristicin all have polar substituents on the aromatic ring, so they may indeed interact with 5-HT2A receptors, but as incomplete (ant)agonists, causing their own unique change in intracellular signalling, resulting in the classic effects of nutmeg (that the above poster is experiencing ).

Hopefully I’ve interpretted the paper correctly, but it sounds to me like some receptor binding assays are in order.

Jochen, what do you think of your discovered metabolites binding with 5-HT2A receptors?

I still contribute the increased energy, focus and rapid heart rate to an interaction between dopegenic and adrenic systoms, most likely indirectly. The empathy is likely tied with the serotonin system, mabe directly or downstream of other actions. Some of the buzz also reminds me of hydrocodone and runners high, so mabe peptide release or direct action at the mu receptor is possible hear too. Bloodshot eyes, dry mouth, and dry mucous membrains all point toward anti-cholergenic action, as does the stoned effect. Anamide (natural THC) may also be involved like in runner’s high.

I took 20 grams (5 nuts) 3.5 hours ago, and starting to feel silly. I may be able to post later tonight, and if not tomorrow.

*volunteers self for scientific purposes*

The first few hours of the day i felt pretty clear and happy at a job i did. around 1pm i had a pilates class in which i was more focused than usual, connecting my brain to my toes/arches very well. after i started to feel like my right front lobe of my brain was moving around and pushing on my right eye, kind of like i my brain was creating new pathways. my eyes became very stoney-like marijuana. And I felt silly, funny, smart, happy, creative and high. I then walked down the street and strolled into a seventies vintage store…i walked out with a whole new outfit and a part of me came out as i walked down the street. I became truly inspired by a vintage amulet necklace i purchased there. I was having all sorts of creative visions and inspirations. I spoke to a friend on the phone and shared some more ideas i had about getting a group together for our friends in our community to share the new evolution of humans into our whole selves and to support this new movement we have all been experiencing figuring out how to live without playing roles.

so around 4pm i had my husband come get me…i was feeling really high by then, increasingly it felt more like shrooms, like my heart was starting to blast open into space. i found it challenging t0 figure out what and how to cook for dinner and put in the kids lunches for the next day. i felt like i was really in my right brain but i tried really hard to do some left brain focus and i was able to ground myself. This is when i found out i was on nutmeg. i thought i was just having an awesome day!

today, a week later i was at a friends house and she made coffee with cream and agave nectar. we put a few dashes of ground nutmeg into our cup. that was 6 hours ago. I definitely got mildly high and feel open and expansive, i little dry eyed/mouthed, and felt like sharing my experience. i wonder if caffeine with the nutmeg might have increased its effects. i have to admit, my interest is peaked in working with its gifts. it doesnt have any of that bad coming off feeling i remember from x or speed that i experimented a little with, maybe because you can sleep on it and it lasts so long and dwindles its effects slowly. and its much more functionable and motivational than chronic marijuana, for me anyway. at least in the smaller dosage that i took… i think i had a quarter to a third of a pod freshly blended.

And i have to say im feeling pretty good right now on only a few dashes in a cup of coffee. i recommend it for fellow pms-ers (those of us on our moon cycle) or anyone who might have the occasional mood swing. seems to a have a nice balancing effect. but i think one time a week is enough in small doses. Maybe it can be used consciously to birth new ideas or dive into creative projects. nothing else has ever appealed to me to use respectfully in this way. Im not a drug user or abuser and barely have a drink but a tequila once in a while. im more interested in more clarity than distraction and numbness. it can be worked with as a plant medicine or guide, more ritualistically. it feels very clean and high in vibration.

Some of the effects, like the closed-eye movies, increased appreciation of humour, and increased empathy, sound similar to the amphetamine analogues of myristicin (MMDA), safrole (MDA), and elemicin (TMA). Read in PiHKAL for the effects of those amphetamines.